The DIVER has been developed in Dr. Mullins' Lab at the University of Washington as a web interface to analyze nucleotide and amino-acid sequence divergence and diversity by performing maximum likelihood phylogenetic analyses. It performs phylogenetic reconstruction via PhyML (v3.0) and Most-Recent-Common-Ancestor (MRCA) sequence determination via HyPhy (v2.0). It provides tools for further data analyses, such as phylogenetic divergence and diversity measurements from the phylogeny, the graphical representation of the inferred tree and plots of divergence and diversity, and distance distribution histograms and summaries. It also provides the functionality to calculate divergence and diversity from a user's pre-specified distance matrix.